A TIMES ENVIRONMENT AND SCIENCE BOOK OF THE YEAR 2022 'The ideal guide to what is not just a fiendishly complex area of science but also an ethical minefield' Mail on Sunday A new gene editing technology, invented just seven years ago, has turned humanity into gods. Enabling us to manipulate the genes in virtually any organism with exquisite precision, CRISPR has given scientists a degree of control that was undreamt of even in science fiction. But CRISPR is just the latest, giant leap in a long journey to master genetics. The Genetic Age shows the astonishing, world-changing potential of the new genetics and the possible threats it poses, sifting between fantasy and the reality when it comes to both benefits and dangers. By placing each phase of discovery, anticipation and fear in the context of over fifty years of attempts to master the natural world, Matthew Cobb, the Baillie-Gifford-shortlisted author of The Idea of the Brain, weaves the stories of science, history and culture to shed new light on our future. With the powers now at our disposal, it is a future that is almost impossible to imagine - but it is one we will create ourselves.

This is the story of our quest to understand the most mysterious object in the universe: the human brain.

Today we tend to picture it as a computer. Earlier scientists thought about it in their own technological terms: as a telephone switchboard, or a clock, or all manner of fantastic mechanical or hydraulic devices. Could the right metaphor unlock the its deepest secrets once and for all?

Galloping through centuries of wild speculation and ingenious, sometimes macabre anatomical investigations, scientist and historian Matthew Cobb reveals how we came to our present state of knowledge. Our latest theories allow us to create artificial memories in the brain of a mouse, and to build AI programmes capable of extraordinary cognitive feats. A complete understanding seems within our grasp.

But to make that final breakthrough, we may need a radical new approach. At every step of our quest, Cobb shows that it was new ideas that brought illumination. Where, he asks, might the next one come from? What will it be?

A TIMES ENVIRONMENT AND SCIENCE BOOK OF THE YEAR 2022 'Brilliant .. I cannot recommend this book strongly enough' - Henry Marsh, New Statesman (about The Idea of the Brain) A new gene editing technology, invented just seven years ago, has turned humanity into gods. Enabling us to manipulate the genes in virtually any organism with exquisite precision, CRISPR has given scientists a degree of control that was undreamt of even in science fiction. But CRISPR is just the latest, giant leap in a long journey to master genetics. The Genetic Age shows the astonishing, world-changing potential of the new genetics and the possible threats it poses, sifting between fantasy and the reality when it comes to both benefits and dangers. By placing each phase of discovery, anticipation and fear in the context of over fifty years of attempts to master the natural world, Matthew Cobb, the Baillie-Gifford-shortlisted author of The Idea of the Brain, weaves the stories of science, history and culture to shed new light on our future. With the powers now at our disposal, it is a future that is almost impossible to imagine - but it is one we will create ourselves.

A gripping and insightful history of the French Resistance and the men and women who opposed Nazi occupation during World War II Based on personal stories, eyewitness accounts, and archival material, this vivid history goes behind the tales of derring-do and explains the forces that shaped the fight against the Nazis, providing a deeper explanation of events. The French resistance to Nazi occupation during World War II was a struggle in which ordinary people fought for their liberty, despite terrible odds and horrifying repression. Hundreds of thousands of Frenchmen and women carried out an armed struggle against the Nazis, producing underground anti-fascist publications and supplying the Allies with vital intelligence. With major themes of courage, self-sacrifice, betrayal, and struggle, this book shatters the illusion of a unified Resistance created by General de Gaulle, and brings to vivid life a true story of heroes and conflicts forgotten over the next half-century as the movement became a myth. Based on hundreds of French eyewitness accounts and including recently-released archival material, this book uses dramatic personal stories to take the reader on one of the great adventures of the 20th century.

'I had thought that for me there could never again be any elation in war. But I had reckoned without the liberation of Paris - I had reckoned without remembering that I might be a part of that richly historic day. We were in Paris on the first day - one of the great days of all time.' (Ernie Pyle, US war correspondent) The liberation of Paris was a momentous point in twentieth-century history, yet it is now largely forgotten outside France. Eleven Days in August is a pulsating hour-by-hour reconstruction of these tumultuous events that shaped the final phase of the war and the future of France, told with the pace of a thriller. While examining the conflicting national and international interests that played out in the bloody street fighting, it tells of how, in eleven dramatic days, people lived, fought and died in the most beautiful city in the world. Based largely on unpublished archive material, including secret conversations, coded messages, diaries and eyewitness accounts, Eleven Days in August shows how these August days were experienced in very different ways by ordinary Parisians, Resistance fighters, French collaborators, rank-and-file German soldiers, Allied and French spies, the Allied and German High Commands. Above all, it shows that while the liberation of Paris may be attributed to the audacity of the Resistance, the weakness of the Germans and the strength of the Allies, the key to it all was the Parisians who by turn built street barricades and sunbathed on the banks of the Seine, who fought the Germans and simply tried to survive until the Germans finally surrendered, in a billiard room at the Prefecture of Police. One of the most iconic moments in the history of the twentieth century had come to a close, and the face of Paris would never be the same again.

Life's Greatest Secret is the story of the discovery and cracking of the genetic code. This great scientific breakthrough has had far-reaching consequences for how we understand ourselves and our place in the natural world. The code forms the most striking proof of Darwin's hypothesis that all organisms are related, holds tremendous promise for improving human well-being, and has transformed the way we think about life. Matthew Cobb interweaves science, biography and anecdote in a book that mixes remarkable insights, theoretical dead-ends and ingenious experiments with the pace of a thriller. He describes cooperation and competition among some of the twentieth century's most outstanding and eccentric minds, moves between biology, physics and chemistry, and shows the part played by computing and cybernetics. The story spans the globe, from Cambridge MA to Cambridge UK, New York to Paris, London to Moscow. It is both thrilling science and a fascinating story about how science is done.

"The most remarkable history of biology that has ever been written."-Michel Foucault Nobel Prize-winning scientist Francois Jacob's The Logic of Life is a landmark book in the history of biology and science. Focusing on heredity, which Jacob considers the fundamental feature of living things, he shows how, since the sixteenth century, the scientific understanding of inherited traits has moved not in a linear, progressive way, from error to truth, but instead through a series of frameworks. He reveals how these successive interpretive approaches-focusing on visible structures, internal structures (especially cells), evolution, genes, and DNA and other molecules-each have their own power but also limitations. Fundamentally challenging how the history of biology is told, much as Thomas Kuhn's Structure of Scientific Revolutions did for the history of science as a whole, The Logic of Life has greatly influenced the way scientists and historians view the past, present, and future of biology.

In this masterful account, a historian of science surveys the molecular biology revolution, its origin and continuing impact. Since the 1930s, a molecular vision has been transforming biology. Michel Morange provides an incisive and overarching history of this transformation, from the early attempts to explain organisms by the structure of their chemical components, to the birth and consolidation of genetics, to the latest technologies and discoveries enabled by the new science of life. Morange revisits A History of Molecular Biology and offers new insights from the past twenty years into his analysis. The Black Box of Biology shows that what led to the incredible transformation of biology was not a simple accumulation of new results, but the molecularization of a large part of biology. In fact, Morange argues, the greatest biological achievements of the past few decades should still be understood within the molecular paradigm. What has happened is not the displacement of molecular biology by other techniques and avenues of research, but rather the fusion of molecular principles and concepts with those of other disciplines, including genetics, physics, structural chemistry, and computational biology. This has produced decisive changes, including the discoveries of regulatory RNAs, the development of massive scientific programs such as human genome sequencing, and the emergence of synthetic biology, systems biology, and epigenetics. Original, persuasive, and breathtaking in its scope, The Black Box of Biology sets a new standard for the history of the ongoing molecular revolution.

Our sense of smell - or olfaction as it is technically known - is our most enigmatic sense. It can conjure up memories, taking us back to very specific places and emotions, whilst powerful smells can induce strong feelings of hunger or nausea. In the animal kingdom smell can be used to find food, a mate, or a home; to sense danger; and to send and receive complex messages with other members of a species. Yet despite its fundamental importance in our mental life and in the existence of all animals, our scientific understanding of how smell works is limited. In this Very Short Introduction, Matthew Cobb describes the latest scientific research on smell in humans and other mammals, in insects, and even in fish. He looks at how smell evolved, how animals use it to navigate and communicate, and disorders of smell in humans. Understanding smell, especially its neurobiology, has proved a big challenge, but olfactory science has revealed genetic factors that determine what we can and cannot smell, and why some people like a given smell while others find it unbearable. He ends by considering future treatments for smell disorders, and speculating on the role of smell in a world of robots. ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.

Insect Taste offers an accessible overview to some of the many advances in insect taste research. The book covers how insects solve the basic problem of taste gustatory processing, from detection and transduction, through coding to the generation of behavior and the evolutionary biology underpinning gustaory learning.

Everyone has heard of the story of DNA as the story of Watson and Crick and Rosalind Franklin, but knowing the structure of DNA was only a part of a greater struggle to understand life's secrets. Life's Greatest Secret is the story of the discovery and cracking of the genetic code, the thing that ultimately enables a spiraling molecule to give rise to the life that exists all around us. This great scientific breakthrough has had farreaching consequences for how we understand ourselves and our place in the natural world, and for how we might take control of our (and life's) future. Life's Greatest Secret mixes remarkable insights, theoretical dead-ends, and ingenious experiments with the swift pace of a thriller. From New York to Paris, Cambridge, Massachusetts, to Cambridge, England, and London to Moscow, the greatest discovery of twentieth-century biology was truly a global feat. Biologist and historian of science Matthew Cobb gives the full and rich account of the cooperation and competition between the eccentric characters--mathematicians, physicists, information theorists, and biologists--who contributed to this revolutionary new science. And, while every new discovery was a leap forward for science, Cobb shows how every new answer inevitably led to new questions that were at least as difficult to answer: just ask anyone who had hoped that the successful completion of the Human Genome Project was going to truly yield the book of life, or that a better understanding of epigenetics or "junk DNA" was going to be the final piece of the puzzle. But the setbacks and unexpected discoveries are what make the science exciting, and it is Matthew Cobb's telling that makes them worth reading. This is a riveting story of humans exploring what it is that makes us human and how the world works, and it is essential reading for anyone who'd like to explore those questions for themselves.

At a time when the complete human genome has been sequenced and when seemingly every week feature news stories describe genes that may be responsible for personality, intelligence, even happiness, Michel Morange gives us a book that demystifies the power of modern genetics. "The Misunderstood Gene" takes us on an easily comprehensible tour of the most recent findings in molecular biology to show us how--and if--genes contribute to biological processes and complex human behaviors.

As Morange explains, if molecular biologists had to designate one category of molecules as essential to life, it would be proteins and their multiple functions, not DNA and genes. Genes are the centerpiece of modern biology because they can be modified. But they are only the memory that life invented so that proteins could be efficiently reproduced. Morange shows us that there is far more richness and meaning in the structure and interactions of proteins than in all the theoretical speculations on the role of genes.

"The Misunderstood Gene" makes it clear that we do not have to choose between rigid genetic determinism and fearful rejection of any specific role for genes in development or behavior. Both are true, but at different levels of organization. Morange agrees with those who say "we are not in our genes." But he also wants us to understand that we are not without our genes, either. We are going to have to make do with them, and this book will show us how.